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- Title
Tissue xanthine oxidoreductase activity in a mouse model of aristolochic acid nephropathy.
- Authors
Ishii, Takeo; Kumagae, Tomohiro; Wakui, Hiromichi; Urate, Shingo; Tanaka, Shohei; Abe, Eriko; Suzuki, Toru; Yamaji, Takahiro; Kinguchi, Sho; Kobayashi, Ryu; Haruhara, Kotaro; Nakamura, Takashi; Kobayashi, Shuzo; Tamura, Kouichi
- Abstract
Xanthine oxidoreductase (XOR) is a critical enzyme in purine metabolism and uric acid production, and its levels are reported to increase during stress, thereby promoting organ damage. Herein, we investigated the activity of XOR in a mouse model of aristolochic acid I (AA)‐induced nephropathy, a type of nephrotoxic chronic kidney disease (CKD). A persistent decrease in renal function was observed in mice up to 4 weeks after 4 weeks of AA (2.5 mg kg−1) administration. Renal histology revealed an increase in tubular interstitial fibrosis over time. Although AA administration did not change XOR activity in the plasma, heart, liver, or muscle, XOR activity was persistently increased in renal tissue. Our results suggest that the renal tissue‐specific increase in XOR activity is involved in the progression of tubulo‐interstitial disorders, specifically fibrosis.
- Subjects
ARISTOLOCHIC acid; XANTHINE; ANIMAL disease models; KIDNEY diseases; ENZYME metabolism
- Publication
FEBS Open Bio, 2021, Vol 11, Issue 2, p507
- ISSN
2211-5463
- Publication type
Article
- DOI
10.1002/2211-5463.13083