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- Title
MiR-29a-3p suppresses cell proliferation in laryngocarcinoma by targeting prominin 1.
- Authors
Jili Su; Eryong Lu; Lijuan Lu; Chao Zhang
- Abstract
MicroRNAs (miRNAs) are known to play a regulatory role in various cancers including laryngocarcinoma. MiR-29a-3p is a potential tumor-suppressive miRNA, but its function in laryngocarcinoma is unknown. The purpose of this study was to investigate the roles of miR-29a-3p in laryngocarcinoma. Prominin1 (PROM1) was predicted as a target gene of miR- 29a-3p and this was verified using a luciferase reporter assay. Transfection of miR-29a-3p into two laryngocarcinoma cell lines indicated that miR- 29a-3p could decrease cell proliferation and enhance the chemotherapy response by targeting PROM1. PROM1 expression was up-regulated in the laryngocarcinoma cells when miR-29a-3p was down-regulated. We found miR-29a-3p expression levels were lower in laryngocarcinoma tissues than in control tissues. We also found that miR-29a-3p expression was negatively correlated with PROM1 expression in laryngocarcinoma tissues. The study demonstrates that miR-29a-3p suppresses cell proliferation in laryngocarcinoma by targeting PROM1.
- Subjects
MICRORNA; LARYNGEAL cancer; TUMOR suppressor genes; PROMININ; INHIBITION of cellular proliferation; GENETICS; THERAPEUTICS
- Publication
FEBS Open Bio, 2017, Vol 7, Issue 5, p645
- ISSN
2211-5463
- Publication type
Article
- DOI
10.1002/2211-5463.12199