We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas.
- Authors
Fedele, Monica; Pentimalli, Francesca; Baldassarre, Gustavo; Battista, Sabrina; Klein-Szanto, Andres J.P.; Kenyon, Lawrence; Visone, Rosa; De Martino, Ivana; Ciarmiello, Andrea; Arra, Claudio; Viglietto, Giuseppe; Croce, Carlo M; Fusco, Alfredo
- Abstract
Overexpression of HMGA1 proteins is a constant feature of human carcinomas. Moreover, rearrangements of this gene have been detected in several human benign tumors of mesenchymal origin. To define the role of these proteins in cell transformation in vivo, we have generated transgenic mice overexpressing ubiquitously the HMGA1 gene. These mice developed mixed growth hormone/prolactin cell pituitary adenomas and natural killer (NK)-T/NK cell lymphomas. The HMGA1-induced expression of IL-2 and IL-15 proteins and their receptors may account for the onset of these lymphomas. At odds with mice overexpressing a wild-type or a truncated HMGA2 protein, adrenal medullar hyperplasia and pancreatic islet cell hyperplasia frequently occurred and no increase in body size and weight was observed in HMGA1 mice. Taken together, these data indicate an oncogenic role of the HMGA1 gene also in vivo.Oncogene (2005) 24, 3427-3435. doi:10.1038/sj.onc.1208501 Published online 28 February 2005
- Subjects
PROTEINS; CANCER; TRANSGENIC animals; LABORATORY mice; PROTEIN hormones; LANGERHANS cells
- Publication
Oncogene, 2005, Vol 24, Issue 21, p3427
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1208501