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- Title
In vivo screening of essential oils of Skimmia laureola leaves for antinociceptive and antipyretic activity
- Authors
Muhammad, Naveed; Barkatullah; Ibrar, Muhammad; Khan, Haroon; Saeed, Muhammad; Khan, Amir Zada; Kaleem, Waqar Ahmad
- Abstract
Abstract: Objective: To study the screening of essential oils of Skimmia laureola leaves (SLO) for acute toxicity, antinociceptive, antipyretic and anticonvulsant activities in various animal models. Methods: SLO were extracted using modified Clevenger type apparatus. Acute toxicity test was used in mice to observe its safety level. Antinociceptive activity of SLO was evaluated in acetic acid induced writhing and hot plate tests. Yeast induced hyperthermic mice and pentylenetetrazole induced convulsive mice were used for the assessment of its antipyretic and anticonvulsant profile respectively. Results: Substantial safety was observed for SLO in acute toxicity test. SLO showed a high significant activity in acetic acid induced writhing test in a dose dependent manner with maximum pain attenuation of 68.48% at 200 mg/kg i.p. However, it did not produce any relief in thermal induced pain at test doses. When challenged against pyrexia evoked by yeast, SLO manifested marked amelioration in hyperthermic mice, dose dependently. Maximum anti-hyperthermic activity (75%) was observed at 200 mg/kg i.p. after 4 h of drug administration. Nevertheless, SLO had no effect on seizures control and mortality caused by pentylenetetrazole. Conclusions: In vivo studies of SLO showed prominent antinociceptive and antipyretic activities with ample safety profile and thus provided pharmacological base for the traditional uses of the plant in various painful conditions and pyrexia. Additional detail studies are required to ascertain its clinical application.
- Subjects
BIOLOGICAL research methodology; ESSENTIAL oils; ORNAMENTAL plants; ANALGESICS; ANTIPYRETICS; ANTICONVULSANTS
- Publication
Asian Pacific Journal of Tropical Biomedicine, 2013, Vol 3, Issue 3, p202
- ISSN
2221-1691
- Publication type
Article
- DOI
10.1016/S2221-1691(13)60050-7