We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
In Vivo Mapping and Quantification of Creatine Using Chemical Exchange Saturation Transfer Imaging in Rat Models of Epileptic Seizure.
- Authors
Lee, Dong-Hoon; Lee, Do-Wan; Kwon, Jae-Im; Woo, Chul-Woong; Kim, Sang-Tae; Lee, Jin Seong; Choi, Choong Gon; Kim, Kyung Won; Kim, Jeong Kon; Woo, Dong-Cheol
- Abstract
<bold>Purpose: </bold>To evaluate signal changes in the hippocampus of epileptic seizure rat models, based on quantified creatine chemical exchange saturation transfer (CrCEST) signals.<bold>Procedures: </bold>CEST data and 1H magnetic resonance spectroscopy (1H MRS) data were obtained for the two imaging groups: control (CTRL) and epileptic seizure-induced (ES; via kainic acid [KA] injection) groups. CrCEST signals in the hippocampal regions were quantitatively evaluated; correlations between CrCEST signals and phosphocreatine (PCr) and total creatine (tCr; PCr + Cr) concentrations, derived from the analysis of 1H MRS data, were investigated as a function of time changes (before KA injection, 3 and 5 h after KA injection).<bold>Results: </bold>Measured CrCEST signals were exhibited significant differences between before and after KA injection in the ES group. At each time point, CrCEST signals showed significant correlations with PCr concentration (all |r| > 0.59; all P < 0.05); no significant correlations were found between CrCEST signals and tCr concentrations (all |r| < 0.22; all P > 0.05).<bold>Conclusions: </bold>CrCEST can adequately detect changes in the concentration of Cr as a result of energy metabolism, and may serve as a potentially useful tool for diagnosis and assessment of prognosis in epilepsy.
- Subjects
MAGNETIZATION transfer; EPILEPSY; NUCLEAR magnetic resonance spectroscopy; CREATINE; RATS
- Publication
Molecular Imaging & Biology, 2019, Vol 21, Issue 2, p232
- ISSN
1536-1632
- Publication type
journal article
- DOI
10.1007/s11307-018-1243-6