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- Title
Comparison of the standard and speckle tracking echocardiographic features of wild-type and mutated transthyretin cardiac amyloidoses.
- Authors
Masatoshi Minamisawa; Jun Koyama; Yoshiki Sekijima; Shu-ichi Ikeda; Ayako Kozuka; Soichiro Ebisawa; Takashi Miura; Hirohiko Motoki; Ayako Okada; Atsushi Izawa; Uichi Ikeda
- Abstract
Aims To compare cardiac function in patients with the two types of transthyretin (TTR)-related amyloidoses [wild-type (wt) and mutated (m) TTR amyloidoses (ATTR)] using standard and speckle tracking echocardiography (STE). Methods Twenty-one consecutive patients with biopsy-proved ATTRwt were compared with 21 patients with ATTRm from the and results database, matched by age and left ventricular (LV) wall thickness (n = 135, ATTRm). All patients were examined using 2D echocardiography. Apical four- and two-chamber, and long-axis views and basal, mid, and apical short-axis views were used to examine LV longitudinal, circumferential, and radial strains. LV ejection fraction (EF), LV basal circumferential/radial strain, and mid-radial strain were significantly lower in patients with ATTRwt compared with patients with ATTRm. There was no significant difference between the two groups in the other parameters. In the receiver-operating characteristic curve analysis, LVEF and LV basal mean radial strain were the best parameters for distinguishing between the two groups. Conclusion Patients with ATTRwt are characterized by lower LVEF, LV basal, and LV mid-radial strains compared with patients with ATTRm. LVEF and LV radial strain are useful in distinguishing between ATTRwt and ATTRm when TTR has been proved in biopsy specimens.
- Publication
European Heart Journal - Cardiovascular Imaging, 2016, Vol 17, Issue 4, p402
- ISSN
2047-2404
- Publication type
Article
- DOI
10.1093/ehjci/jew003