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- Title
Amphiphilic Cyanine-Platinum Conjugates as Fluorescent Nanodrugs.
- Authors
Sun, Tingting; Li, Zhensheng; Xie, Zhigang; Jing, Xiabin
- Abstract
Two fluorescent nanomedicines based on small molecular cyanine-platinum conjugates have been prepared via a nanoprecipitation method and characterized by transmission electron microscopy (TEM) as well as dynamic light scattering (DLS). The conjugates exhibited an enhanced fluorescence in their nanoparticle formulation compared to that in solution. The nanomedicines could be endocytosed by cancer cells as revealed by confocal laser scanning microscopy (CLSM) and showed high cellular proliferation inhibition. Fluorescent platinum nanomedicines prepared directly from small molecules could be an alternative strategy for developing new drugs with simultaneous cellular imaging and cancer therapy functions.
- Subjects
NANOMEDICAL research; TRANSMISSION electron microscopy; CYANINES; PLATINUM catalysts; CELL proliferation
- Publication
Chemistry - An Asian Journal, 2016, Vol 11, Issue 2, p221
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.201501163