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- Title
Enhancer Function in the 3D Genome.
- Authors
Razin, Sergey V.; Ulianov, Sergey V.; Iarovaia, Olga V.
- Abstract
In this review, we consider various aspects of enhancer functioning in the context of the 3D genome. Particular attention is paid to the mechanisms of enhancer-promoter communication and the significance of the spatial juxtaposition of enhancers and promoters in 3D nuclear space. A model of an activator chromatin compartment is substantiated, which provides the possibility of transferring activating factors from an enhancer to a promoter without establishing direct contact between these elements. The mechanisms of selective activation of individual promoters or promoter classes by enhancers are also discussed.
- Subjects
CHROMATIN; PHASE separation
- Publication
Genes, 2023, Vol 14, Issue 6, p1277
- ISSN
2073-4425
- Publication type
Article
- DOI
10.3390/genes14061277