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- Title
Clinical Features and Prognosis Analysis of Hodgkin Lymphoma: A Multicenter Retrospective Study Over a Decade of Patients in China.
- Authors
Yu, Wen-Yan; Geng, Mei; Hao, Jie; Chen, Mei; Zhang, Su-Jiang; Wang, Jin; Mi, Jian-Qing
- Abstract
<bold>Objective: </bold>There is little information available regarding Chinese patients with Hodgkin lymphoma (HL). We analyzed the clinical features, outcome, and prognostic factors of Chinese patients with HL, aiming to establish a new risk model for better risk-adapted therapeutic strategy.<bold>Patients and Methods: </bold>Patients with newly diagnosed HL at 4 medical centers from January 2000 to August 2014 were recruited.<bold>Results: </bold>A total of 150 patients were reviewed. The median age was 30 years (range, 15-91 years). At completion of initial therapy, 73.65% of patients achieved complete remission. The 5-year event-free survival (EFS) of the entire cohort was 61.1%, the overall survival was 84.7%, and the disease-free survival was 78.8%. B symptoms, extranodal involvement, and International Prognostic Score ≥ 3 remained as independent prognostic factors of EFS. Patients who failed to reach complete remission on interim positron emission tomography/computed tomography or computed tomography had a significantly worse outcome than those who did. A new risk model incorporating traditional risk factors and interim response stratified patients into 3 classes, with a 5-year EFS of 100%, 83.1%, and 33.1%, respectively (P < .0001).<bold>Conclusions: </bold>General clinical features were comparable with those of Western patients, whereas therapeutic outcomes were slightly inferior. The novel risk assessment model showed potential as a more powerful prognostic tool by identifying 3 subsets of patients with significantly distinct outcomes, which warrants further validations.
- Subjects
CHINA; ANTINEOPLASTIC agents; HODGKIN'S disease treatment; COMPARATIVE studies; HODGKIN'S disease; RESEARCH methodology; MEDICAL cooperation; PROGNOSIS; RADIOTHERAPY; RESEARCH; EVALUATION research; PROPORTIONAL hazards models; RETROSPECTIVE studies; KAPLAN-Meier estimator
- Publication
Clinical Lymphoma, Myeloma & Leukemia, 2017, Vol 17, Issue 5, p274
- ISSN
2152-2650
- Publication type
journal article
- DOI
10.1016/j.clml.2017.02.005