We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Serum Neurotensin: An Objective Mirror to Acne-induced Quality of Life and Psychological Impairment.
- Authors
MIKHAEL, NANCY W.; MANSOUR, AMIRA I.; EL DIN, ESRAA M. SALAH; EL AZAB, MOHAMMED HAMMAD; SALEM, REHAB M.; Salah El Din, Esraa M
- Abstract
<bold>Background: </bold>Acne is a multifactorial disorder, and stress potentially plays a role in its pathogenesis.<bold>Objectives: </bold>We aimed to assess the serum levels of neurotensin in patients with acne vulgaris (AV) and investigate the relationship of these levels to quality of life (QoL), depression, anxiety, and stress.<bold>Methods: </bold>The study included 60 patients with AV classified into mild (n=20), moderate (n=20), and severe (n=20) groups and 20 healthy, age-matched, sex-matched, and body mass index (BMI)-matched individuals in a control group. Patient QoL was assessed using the Dermatology Life Quality Index (DLQI). Each participant completed the Hospital Anxiety and Depression Scale (HADS) and Perceived Stress Scale (PSS-10). Serum levels of neurotensin were measured with enzyme-linked immunosorbent assay (ELISA).<bold>Results: </bold>Neurotensin levels and scores from the three questionnaires were significantly higher among the patients with AV than the control subjects. They were also significantly elevated in patients with post-acne scars and hyperpigmentation and in those with severe acne.<bold>Conclusion: </bold>It is well known that acne greatly impacts QoL and might be associated with depression, anxiety, and stress. Further, serum neurotensin could be a promising marker to objectively evaluate the psychosocial impact of AV.
- Subjects
NEUROTENSIN; PERCEIVED Stress Scale; ENZYME-linked immunosorbent assay; QUALITY of life; ACNE
- Publication
Journal of Clinical & Aesthetic Dermatology, 2021, Vol 14, Issue 12, pE69
- ISSN
1941-2789
- Publication type
journal article