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- Title
Improving Care for Heart Failure With Reduced Ejection Fraction-A Potential Polypill-Based Strategy.
- Authors
Agarwal, Anubha; Yancy, Clyde W.; Huffman, Mark D.
- Abstract
This Viewpoint proposes that a polypill combination of a β-blocker, renin angiotensin inhibitor, mineralocorticoid receptor antagonist, and sodium-glucose cotransporter 2 inhibitor might be the most efficient way to deliver guideline-directed HFrEF therapy, and proposes a research roadmap to design and evaluate the pill and implementation strategies for getting it to patients.
- Subjects
HEART failure; ADRENERGIC beta blockers; RENIN-angiotensin system; NEPRILYSIN; MINERALOCORTICOIDS; COMBINATION drug therapy; MEDICAL protocols; DRUGS; ALDOSTERONE antagonists; STROKE volume (Cardiac output); ANGIOTENSIN receptors; PATIENT compliance
- Publication
JAMA: Journal of the American Medical Association, 2020, Vol 324, Issue 22, p2259
- ISSN
0098-7484
- Publication type
journal article
- DOI
10.1001/jama.2020.21395