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- Title
Role of blood markers in diagnostics of an age cataract.
- Authors
KUDRYAVTSEVA, YV; CHUPROV, AD; TSIBEL, VB; BOJKO, ER
- Abstract
Purpose To reveal in a blood some markers of changes in a lens during development of a senile cataract. Methods Objects of research were 134 patients at the age from 43 till 84 years, operated concerning a cataract. We determined degree of a cataract maturity and estimated degree of a brown shade of a lens nucleus. The molecular products of peroxidation (primary, secondary, end‐products of a lipidic and proteic genesis), enzymes of antioxidants (glutationperoxidasa, glutationreductasa, superoxide scavenger), natural antioxidants (Retinolum, tocopherol, selenium in a blood were defined. Results During the development of an age cataract the level of peroxidatoin products ‐ dienic conjugates, crotonic aldehyde and the bases of Shiffa are decreasing. Decrease of content of vitamins В2, A and Е if the intensifying of a brown shade of a lens nucleus was revealed. The content of dienic conjugates decreases, the level of crotonic aldehyde increases and the concentration of the bases of Shiffa also change. The content of selenium in a blood decreases in patients with a brown cataract but it doesn't change in patients with mature cataract. Conclusion There are markers in a blood in patients with a cataract which change at advance of opacifications and intensifying of brown colour of a lens nucleus. However its changes is non‐specific and means about the general activation of processes of peroxidation and antioxidatic system
- Subjects
CRYSTALLINE lens; CATARACT; CROTONALDEHYDE; VITAMIN E
- Publication
Acta Ophthalmologica (1755375X), 2010, Vol 88, p0
- ISSN
1755-375X
- Publication type
Article
- DOI
10.1111/j.1755-3768.2010.427.x