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- Title
Incidence, severity, longitudinal trends and predictors of acute and chronic oxaliplatin‐induced peripheral neuropathy in Taiwanese patients with colorectal cancer.
- Authors
Hsu, Shu‐Yi; Huang, Wen‐Shih; Lee, Shu‐Hui; Chu, Tsui‐Ping; Lin, Yung‐Chang; Lu, Chang‐Hsien; Beaton, Randal D.; Jane, Sui‐Whi
- Abstract
The purpose of this study was to evaluate the longitudinal incidence, severity, pattern of changes or predictors of oxaliplatin‐induced peripheral neuropathy (OXAIPN) in Taiwanese patients with colorectal cancer. A longitudinal repeated measures study design was employed, and 77 participants were recruited from the colorectal and oncology departments of two teaching medical centres in Taiwan. Physical examinations were performed, and self‐reports regarding adverse impacts of OXAIPN and quality of life were obtained at five time points throughout 12 cycles of chemotherapy (C/T). The incidence of OXAIPN increased with C/T cycles (31.1%–81.9%), and the upper limb numbness and cold sensitivity were most significant acute OXAIPN symptoms (29.9%–73.6%). Findings also documented significant increases in overall severity, symptom distress, interference and physical results associated with OXAIPN over the course of C/T. Predictors of OXAIPN severity varied by treatment cycle, including younger patient, higher cumulative dose of oxaliplatin, greater body surface area, receipt of chemotherapy in winter and the occurrence of OXAIPN during prior C/T cycles. The results from this study might help healthcare providers to recognise the symptom characteristics, degree of influences, trends and high‐risk group of OXAIPN, facilitating early evaluation and potential interventions to mitigate or prevent negative effects of OXAIPN on patients.
- Subjects
TAIWAN; ACADEMIC medical centers; ANTHROPOMETRY; ARM; CANCER chemotherapy; CANCER patient psychology; CHRONIC diseases; COLD (Temperature); COLON tumors; PSYCHOLOGICAL distress; LIFE skills; LONGITUDINAL method; PERIPHERAL neuropathy; PHYSICAL diagnosis; QUALITY of life; QUESTIONNAIRES; RECTUM tumors; RESEARCH funding; RISK assessment; SEASONS; SELF-evaluation; SEX distribution; TACTILE agnosia; SYMPTOMS; OXALIPLATIN; REPEATED measures design; SEVERITY of illness index; ACUTE diseases; BODY surface area; TREATMENT duration; DATA analysis software; DESCRIPTIVE statistics
- Publication
European Journal of Cancer Care, 2019, Vol 28, Issue 2, pN.PAG
- ISSN
0961-5423
- Publication type
Article
- DOI
10.1111/ecc.12976