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- Title
Clinical observation on the efficacy of Cyber Knife for primary or metastatic retroperitoneal tumours.
- Authors
Zhuang, H‐Q.; Yuan, Z‐Y.; Song, Y‐C.; Wang, J.; Zhao, L‐J.; Wang, P.
- Abstract
The aim of the paper is to evaluate the efficacy of Cyber Knife® for the treatment of primary or metastatic retroperitoneal tumours. Twenty-eight patients were treated. The prescription isodose line (median, 78%; range, 70-84%) covered the planning target volume at a total dose of 2000-6000 cGy (median, 4500 cGy) and a biologically effective dose of 3750-10 080 cGy (median, 7680 cGy) in 2-10 fractions (median, five fractions). The results showed that the complete response, partial response, stable disease, and progressive disease rates were 43% (12/28), 36% (10/28), 18% (5/28), and 4% (1/28) respectively. The overall response rate was 96%. The 1-, 2- and 3-year local control rates were 92%, 86%, and 86% respectively. The 1-, 2- and 3-year overall survival rates were 60%, 49%, and 49% respectively. No significant difference was found between local progression-free survival and overall survival. Moreover, if a patient only had metastases in the retroperitoneum and local control was effective, there was no significant difference between local progression-free survival and overall progression-free survival. In conclusion, Cyber Knife treatment for retroperitoneal tumours resulted in high response rates with minimal side effects. All radiation-induced side effects were well tolerated.
- Subjects
CHINA; RADIOSURGERY; ACADEMIC medical centers; CHI-squared test; MEDICAL records; METASTASIS; HEALTH outcome assessment; SURVIVAL; RETROPERITONEUM; EQUIPMENT &; supplies; TREATMENT effectiveness; RETROSPECTIVE studies; DATA analysis software; DESCRIPTIVE statistics; KAPLAN-Meier estimator; LOG-rank test; TUMORS
- Publication
European Journal of Cancer Care, 2014, Vol 23, Issue 1, p76
- ISSN
0961-5423
- Publication type
Article
- DOI
10.1111/ecc.12112