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- Title
Circulating adipokines are associated with Kawasaki disease.
- Authors
Zhang, Xin-yan; Yang, Ting-ting; Hu, Xiu-fen; Wen, Yu; Fang, Feng; Lu, Hui-ling
- Abstract
Background: The pathogenesis of Kawasaki disease are still not well understood. It was designed to investigate the relationship between adipokines including chemerin, omentin-1, adiponectin and acute Kawasaki disease. Methods: Enzyme-linked immunosorbent (ELISA) was used to detect serum levels of chemerin, omentin-1, adiponectin, and inflammatory cytokines IL-1β and TNF-α in 80 cases of patients diagnosed with Kawasaki disease (KD). In addition, 20 cases of children with fever and 20 cases of healthy children were selected as febrile and normal controls. Results: (1) Serum levels of chemerin in KD group (87.736 ± 56.310) are higher than that of both the healthy (41.746 ± 10.824) and the febrile controls (59.683 ± 18.282) (<italic>P</italic> < 0.01). (2) Circulating omentin-1 levels in Kawasaki disease group (389.773 ± 238.611) are significantly lower than that of febrile control (542.075 ± 177.995) (<italic>P</italic> < 0.01), also serum adiponectin levels in Kawasaki disease group (16.400 ± 12.243) reduced obviously compared with the febrile control group (35.074 ± 12.486). (3)Serum cytokine levels of IL-1β in Kawasaki disease group (13.656 ± 31.151) are higher than those of normal controls (2.415 ± 6.313) (<italic>P</italic> < 0.05). (4) Correlation analysis indicates that serum levels of chemerin are positively correlated with omentin-1 (<italic>r</italic> = 0.224, 95% CI 0.06–0.529, <italic>P</italic> < 0.05). Further, serum omentin-1 levels and total cholesterol (TC) are positively correlated (<italic>r</italic> = 0.358, 95% CI 0.169–0.518, <italic>P</italic> < 0.01). Conclusions: Circulating chemerin increased significantly in the acute stage of Kawasaki disease, while omentin-1 and adiponectin levels are decreased. These adipokines are closely associated with the early inflammation and lipid metabolism disorders of acute Kawasaki disease.
- Subjects
ADIPOKINES; MUCOCUTANEOUS lymph node syndrome; ADIPONECTIN; CHEMERIN; ENZYME-linked immunosorbent assay
- Publication
Pediatric Rheumatology, 2018, Vol 16, Issue 1, pN.PAG
- ISSN
1546-0096
- Publication type
Article
- DOI
10.1186/s12969-018-0243-z