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- Title
Association of HLA-DQB1 polymorphisms with rheumatoid arthritis: a meta-analysis.
- Authors
Jun Wu; Jun Li; Si Li; Tian-Ping Zhang; Lian-Ju Li; Tian-Tian Lv; Hai-Feng Pan; Dong-Qing Ye; Wu, Jun; Li, Jun; Li, Si; Zhang, Tian-Ping; Li, Lian-Ju; Lv, Tian-Tian; Pan, Hai-Feng; Ye, Dong-Qing
- Abstract
<bold>Aim: </bold>Studies investigating the association between HLA-DQB1 alleles and rheumatoid arthritis (RA) have reported conflicting results. The purpose of this study was to evaluate whether DQB1 alleles confer susceptibility to RA.<bold>Design: </bold>A comprehensive literature search up to May 2016 was conducted to identify case-control studies on the association of HLA-DQB1 alleles with RA. Pooled ORs with 95% CIs were used to assess the strength of association.<bold>Setting: </bold>The literature indicates that HLA-DQB1 is associated with susceptibility to RA.<bold>Main Outcome Measures: </bold>Frequencies of HLA-DQB1 alleles and phenotype in RA patients and healthy controls.<bold>Results: </bold>Fifteen studies with 1250 cases and 1621 controls were included in this meta-analysis. DQB1 alleles were associated with RA susceptibility. The frequencies of DQB1*06 were lower in RA (p-value for comparability=0.007, OR 0.726,95% CI 0.576 to 0.916; p=0.004, OR 0.611,95% CI 0.438 to 0.852). The frequencies of DQB1*02 were lower in RA (p=0.044, OR 0.731,95% CI 0.597 to 0.895). A higher frequency of DQB1*04 was observed in RA (p=0.023, OR 1.604,95% CI 1.067 to 2.410).<bold>Conclusions: </bold>This meta-analysis demonstrates that DQB1*02 and DQB1*06 may be negatively associated with RA. Conversely, DQB1*04 may confer susceptibility to RA.
- Subjects
RHEUMATOID arthritis; HLA histocompatibility antigens; ALLELES; CASE-control method; HISTOCOMPATIBILITY; COMPARATIVE studies; DISEASE susceptibility; GENETIC polymorphisms; RESEARCH methodology; MEDICAL cooperation; META-analysis; RESEARCH; HLA-B27 antigen; PHENOTYPES; EVALUATION research
- Publication
Postgraduate Medical Journal, 2017, Vol 93, Issue 1104, p618
- ISSN
0032-5473
- Publication type
journal article
- DOI
10.1136/postgradmedj-2016-134724