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- Title
Catheter-directed laser coagulation of atrial myocardium in dogs.
- Authors
WEBER, H. P.; HEINZE, A.; ENDERS, S.; RUPRECHT, L.; UNSöLD, E.
- Abstract
The feasibility of transcatheter laser coagulation of atrial myocardium was tested in a canine model by using a combined electrode-laser catheter. In 17 anaesthetized beagles a total of 264 lesions, 12–19 per dog, and 3–5 in each area were produced in: (1) the lateral walls, (2) the posterior right atrial walls, (3) the inter-atrial septum, and (4) the atrial appendage. The power source was a continuous wave Nd: YAG laser. Irradiance was 1 kW. cm, at a wave length of 1064 nm, the irradiated spot diameter was 2.0–2.5 mm, and the pulse duration 5–60 s. Local intra-cardiac atrial potentials recorded from the targeted areas during laser irradiation dwindled after onset of the laser pulse, and their amplitude was reduced persistently by pulses of 15 s or longer. Histopathologically, the acute lesions showed intramural haemorrhage and coagulation necrosis, but there was no tissue vaporization or crater formation. Chronic lesions showed clear-cut oval-shaped areas of transmural fibrosis. Diameters of lesions, dependent on the amount of laser energy applied, measured from 4.6 ± 0.5 mm (450 J) to 7.8 ±1.4 mm (1800 J). Follow-up lasted 6–25 months (average 10.5). All the animals survived the procedure without complications. Transcatheter laser coagulation of atrial myocardium is safe and can be performed in a controllable manner by using the catheter system presented.
- Publication
European Heart Journal, 1994, Vol 15, Issue 7, p971
- ISSN
0195-668X
- Publication type
Article
- DOI
10.1093/oxfordjournals.eurheartj.a060618