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- Title
Directional Potassium Transport through a Unimolecular Peptide Channel.
- Authors
Su, Ge; Zhang, Min; Si, Wen; Li, Zhan‐Ting; Hou, Jun‐Li
- Abstract
Three unimolecular peptide channels have been designed and prepared by using the β-helical conformation of gramicidin A (gA). The new peptides bear one to three NH3+ groups at the N-end and one to three CO2− groups at the C-end. These zwitterionic peptides were inserted into lipid bilayers in an orientation-selective manner. Conductance experiments on planar lipid bilayers showed that this orientation bias could lead to observable directional K+ transport under multi-channel conditions. This directional transport behavior can further cause the generation of a current across a planar bilayer without applying a voltage. More importantly, in vesicles with identical external and internal KCl concentrations, the channels can pump K+ across the lipid bilayer and cause a membrane potential.
- Subjects
GRAMICIDINS; PEPTIDES; ZWITTERIONS; ELECTRIC admittance; ANTIBIOTICS
- Publication
Angewandte Chemie International Edition, 2016, Vol 55, Issue 47, p14678
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201608428