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- Title
Cobalt-Catalyzed Hydrogenation of Esters to Alcohols: Unexpected Reactivity Trend Indicates Ester Enolate Intermediacy.
- Authors
Srimani, Dipankar; Mukherjee, Arup; Goldberg, Alexander F. G.; Leitus, Gregory; Diskin-Posner, Yael; Shimon, Linda J. W.; Ben David, Yehoshoa; Milstein, David
- Abstract
The atom-efficient and environmentally benign catalytic hydrogenation of carboxylic acid esters to alcohols has been accomplished in recent years mainly with precious-metal-based catalysts, with few exceptions. Presented here is the first cobalt-catalyzed hydrogenation of esters to the corresponding alcohols. Unexpectedly, the evidence indicates the unprecedented involvement of ester enolate intermediates.
- Subjects
COBALT catalysts; HYDROGENATION; ESTERS; ALCOHOLS (Chemical class); ATOMS; INTERMEDIATES (Chemistry)
- Publication
Angewandte Chemie International Edition, 2015, Vol 54, Issue 42, p12357
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201502418