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- Title
Palladium-Catalyzed Direct Cyclopropylation of Heterocycles.
- Authors
Wu, Xiaojin; Lei, Chuanhu; Yue, Guizhou; Zhou, Jianrong (Steve)
- Abstract
Many 1,3-azoles and thiophenes are directly cyclopropylated in the presence of a simple palladium catalyst. The relative configuration on the three-membered rings is retained in the products. Thus, the cyclopropyl-halide bond undergoes concerted oxidative addition to palladium(0) and cyclopropyl radicals are not involved in the productive pathway.
- Subjects
HETEROCYCLIC compounds; PALLADIUM catalysts; CATALYSIS; AZOLES; THIOPHENES; CYCLOPROPYL compounds; CHEMICAL bonds
- Publication
Angewandte Chemie International Edition, 2015, Vol 54, Issue 33, p9601
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201504735