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- Title
A Metal-Free Multicomponent Cascade Reaction for the Regiospecific Synthesis of 1,5-Disubstituted 1,2,3-Triazoles.
- Authors
Cheng, Guolin; Zeng, Xiaobao; Shen, Jinhai; Wang, Xuesong; Cui, Xiuling
- Abstract
About specifics: A method for the regiospecific synthesis of the title compounds through an unprecedented Michael addition/deacylative diazo transfer/cyclization sequence has been established. The simple and practical method can be used for the modification of primary amines including chiral α‐amines. The process involves the formation three covalent bonds and the cleavage of two covalent bonds (see scheme, Ts=4‐toluenesulfonyl).
- Subjects
TRIAZOLES synthesis; DIAZO reaction; RING formation (Chemistry); SULFONYL azides; AMINE synthesis; COVALENT bonds; SCISSION (Chemistry)
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 50, p13265
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201307499