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- Title
Palladium- and Ruthenium-Catalyzed Cycloisomerization of Enynamides and Enynhydrazides: A Rapid Approach to Diverse Azacyclic Frameworks.
- Authors
Walker, P. Ross; Campbell, Craig D.; Suleman, Abid; Carr, Greg; Anderson, Edward A.
- Abstract
I want to ride my azacycle: The title reaction of enynamides affords a wide diversity of azacycles. The reactions are high‐yielding, highly stereoselective, and proceed rapidly under mild reaction conditions. Equivalent transformations using enynhydrazides offer new routes to pyrazole and indazole scaffolds. Boc=tert‐butoxycarbonyl, EWG=electron‐withdrawing group, Ns=4‐nitrobenzenesulfonyl, Ts=4‐toluenesulfonyl.
- Subjects
CYCLOISOMERIZATION; ENYNES; HYDRAZIDES; PALLADIUM catalysts; RUTHENIUM catalysts; HOMOGENEOUS catalysis; REGIOSELECTIVITY (Chemistry)
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 35, p9139
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201304186