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- Title
Stoichiometric Leverage: Rapid <sup>18</sup>F-Aryltrifluoroborate Radiosynthesis at High Specific Activity for Click Conjugation.
- Authors
Liu, Zhibo; Li, Ying; Lozada, Jerome; Schaffer, Paul; Adam, Michael J.; Ruth, Thomas J.; Perrin, David M.
- Abstract
Raising the18F3‐BAr: Specific activities of most 18F‐labeled radiotracers fall below 2 Ci μmol−1, yet 18F‐aryltrifluoroborate synthesis affords specific activities as high as 15 Ci μmol−1. This has been confirmed by using click chemistry to link an [18F]‐ArBF3− to rhodamine and thereby demonstrating a rapid and generalizable one‐pot method for preparing a fluorescent tracer with about 10‐fold higher specific activity than usual.
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 8, p2303
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201208551