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- Title
Implications of Epstein–Barr Virus (EBV)-Induced Carcinogenesis on Cutaneous Inflammation and Carcinogenesis: Evidence of Recurring Patterns of Angiogenesis and Signal Transduction.
- Authors
Arbiser, Jack L.
- Abstract
The article discusses the implications of epstein-barr virus (EBV)-induced carcinogenesis on cutaneous inflammation and carcinogenesis. The three most common cancers of the skin are basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma. In BCC and SCC, mutations of p53 are extremely common, whereas in melanoma, loss of p1 6ink4a is very common. The most important carcinogen in terms of the skin is ultraviolet light, with UVB capable of causing direct DNA damage as well as reactive oxygen generation, whereas UVA is less damaging to DNA, but causes generation of reactive oxygen.
- Subjects
SQUAMOUS cell carcinoma; SKIN cancer; NUCLEIC acids; NEUROENDOCRINE tumors; MELANOMA; DNA damage
- Publication
Journal of Investigative Dermatology, 2005, Vol 124, Issue 5, p11
- ISSN
0022-202X
- Publication type
Editorial
- DOI
10.1111/j.0022-202X.2005.23695.x