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- Title
Mortality and morbidity in non‐transfusable and transfusable patients: A systematic review and meta‐analysis.
- Authors
Seeber, Petra; Döbel, Kai‐Uwe; Isbister, James P.; Murray, Kevin; Shander, Aryeh; Trentino, Kevin M.; Lucas, Matthias
- Abstract
Keywords: anemia; outcome; patient blood management; transfusion EN anemia outcome patient blood management transfusion 685 697 13 03/23/22 20220301 NES 220301 Abbreviations PBM Patient Blood Management PRISMA Preferred Reporting Items for Systematic Reviews and Meta-Analyses SABM Society for the Advancement of Blood Management NATA Network for the Advancement of Patient Blood Management, Hemostasis and Thrombosis ICU Intensive Care Unit DIC Disseminated intravascular coagulation ROBINS-I Risk Of Bias in Non randomised Studies of Intervention INTRODUCTION Anemia is associated with adverse outcome in a severity-dependent fashion, commencing with slight deviations from normal hemoglobin levels.1,2 At a certain degree of anemia, known as the transfusion threshold or trigger, allogeneic red cell transfusions are administered with the purpose of reducing the increased morbidity and mortality observed. We defined non-transfusable as: patients declining allogeneic transfusions (regardless of reason); patients treated under conditions where transfusions were not available (pandemics, disasters, combat settings, resource limited countries); patients with rare blood types or complex antibody patterns for whom no transfusions are available. PBM is "the science of optimizing patient outcomes through the judicious use of the patient's own blood as a patient-centered, multidisciplinary and multimodal approach to patient care. Over the past 20 years, there has been growing interest in patient outcomes following allogeneic transfusions, particularly in identifying which patients are most likely to benefit from red cell transfusions and at which hemoglobin threshold.
- Subjects
RED blood cell transfusion; HEART assist devices; GASTROINTESTINAL hemorrhage; MYOCARDIAL infarction; CORONARY artery bypass
- Publication
Transfusion, 2022, Vol 62, Issue 3, p685
- ISSN
0041-1132
- Publication type
Article
- DOI
10.1111/trf.16788