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- Title
ACUTE ALACHLOR AND BUTACHLOR HERBICIDE POISONING.
- Authors
Lo, Y. C.; Yang, C. C.; Deng, J. F.
- Abstract
Objective: Alachlor and butachlor are commonly used herbicides. Data on related acute human poisonings, however, are scarce. We retrospectively analyzed the data of human alachlor/butachlor poisoning in Taiwan. Methods: From October 1986 through February 2007, 63 alachlor and 70 butachlor poisoning cases were reported to the Taiwan National Poison Center. Their clinical data were reviewed and analyzed. Results: Most cases intentionally ingested the herbicides. The toxicities of alachlor and butachlor were largely similar. Twenty-eight out of 102 patients with oral exposure were asymptomatic, while the others developed vomiting, central nervous system depression, and other outcomes. Among patients involving other exposure pathways, gastrointestinal effects were the main manifestation. Three patients died after manifesting profound hypotension and/or coma following alachlor ingestion. Conclusion: Alachlor and butachlor poisonings are usually of low toxicity. However, severe neurological and cardiovascular outcomes could rarely develop, especially following oral ingestion. Medical management of such poisonings is primarily supportive.
- Subjects
HERBICIDE toxicology
- Publication
Journal of Medical Toxicology, 2008, Vol 4, Issue 3, p212
- ISSN
1556-9039
- Publication type
Abstract