We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The association of HLA-DQB1*0602 but not HLA-DRB1*15 with obstructive sleep apnea.
- Authors
Momany, Suleiman M.; Al-Qatarneh, Thamer A.; Khader, Yousef S.; Abu-Harfeil, Nizar M.; Daoud, Ammar K.; Mahasneh, Amjad A.
- Abstract
<bold>Purpose: </bold>Obstructive sleep apnea (OSA) is a sleep breathing disorder with unclear multifactorial pathogenesis. This study aimed to investigate the association between OSA and two human leukocyte antigens (HLA) alleles; DQB1*0602 and DRB1*15.<bold>Methods: </bold>Forty patients with OSA and 40 control subjects were enrolled in the study. OSA diagnosis was made utilizing the Apnea-Hypopnea Index (AHI)≥5 in overnight polysomnography (PSG). AHI was also used to determine OSA severity. Controls were randomly selected from healthy volunteers who had a low risk for OSA, utilizing the Berlin Questionnaire. Polymerase chain reaction (PCR) using Sequence Specific Primers (PCR-SSPs) was used to determine the association between HLA (HLA-DQB1*0602 and HLA-DRB1*15) and OSA, then statistical analyses of the results were performed.<bold>Results: </bold>HLA-DQB1*0602 allele was found in 85% of all OSA patients and 50% of controls (P< 0.001). In patients with severe OSA, HLA-DQB1*0602 was present in the 92.9% compared with 66.7% in non-severe OSA (P=0.05). HLA-DRB1*15 allele was found in 15% of OSA patients and 20% of controls, with no difference between the two groups (P=0.556). No statistical difference was found in HLA-DRB1*15 between severe and non-severe OSA (P=0.499). After adjusting for gender, HLA-DQB1*0602 allele was associated with increased odds of OSA (OR = 6.17, 95% CI 1.87-20.3, p = 0.003), but HLA-DRB1*15 allele was not associated with OSA (OR 0.45, 95% CI 0.12-1.73, p = 0.242).<bold>Conclusions: </bold>The presence of HLA-DQB1*0602 allele, but not HLA-DRB1*15 allele, was significantly associated with OSA.
- Subjects
SLEEP apnea syndromes; LEUCOCYTES; ANTIGENS; POLYMERASE chain reaction; ALLELES
- Publication
Clinical & Investigative Medicine, 2017, Vol 40, Issue 4, pE167
- ISSN
0147-958X
- Publication type
journal article
- DOI
10.25011/cim.v40i4.28494