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Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes.
Published in:
2016
By:
- Bruhn, David F.;
- Wyllie, Susan;
- Rodríguez-Cortés, Adaris;
- Carrillo, Angela K.;
- Rakesh;
- Kiplin Guy, R.;
- Fairlamb, Alan H.;
- Lee, Richard E.;
- Guy, R Kiplin
Publication type:
journal article
Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins.
Published in:
Science Signaling, 2018, v. 11, n. 543, p. 1, doi. 10.1126/scisignal.aaq1077
By:
- Ippagunta, Sirish K.;
- Pollock, Julie A.;
- Sharma, Naina;
- Lin, Wenwei;
- Chen, Taosheng;
- Tawaratsumida, Kazuki;
- High, Anthony A.;
- Min, Jaeki;
- Chen, Yizhe;
- Guy, R. Kiplin;
- Redecke, Vanessa;
- Katzenellenbogen, John A.;
- Häcker, Hans
Publication type:
Article
Searching for New Antimalarial Therapeutics amongst Known Drugs.
Published in:
Chemical Biology & Drug Design, 2006, v. 67, n. 6, p. 409, doi. 10.1111/j.1747-0285.2006.00391.x
By:
- Weisman, Jennifer L.;
- Liou, Ally P.;
- Shelat, Anang A.;
- Cohen, Fred E.;
- Guy, R. Kiplin;
- DeRisi, Joseph L.
Publication type:
Article
Discovery of Trypanocidal Compounds by Whole Cell HTS of Trypanosoma brucei.
Published in:
Chemical Biology & Drug Design, 2006, v. 67, n. 5, p. 355, doi. 10.1111/j.1747-0285.2006.00389.x
By:
- Mackey, Zachary B.;
- Baca, Arthur M.;
- Mallari, Jeremy P.;
- Apsel, Beth;
- Shelat, Anang;
- Hansell, Elizabeth J.;
- Chiang, Peter K.;
- Wolff, Brian;
- Guy, Kiplin R.;
- Williams, Janice;
- McKerrow, James H.
Publication type:
Article
Similarly efficacious anti-malarial drugs SJ733 and pyronaridine differ in their ability to remove circulating parasites in mice.
Published in:
Malaria Journal, 2022, v. 21, n. 1, p. 1, doi. 10.1186/s12936-022-04075-z
By:
- SheelaNair, Arya;
- Romanczuk, Aleksandra S.;
- Aogo, Rosemary A.;
- Haldar, Rohit Nemai;
- Lansink, Lianne I. M.;
- Cromer, Deborah;
- Salinas, Yandira G.;
- Guy, R. Kiplin;
- McCarthy, James S.;
- Davenport, Miles P.;
- Haque, Ashraful;
- Khoury, David S.
Publication type:
Article
Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones.
Published in:
Malaria Journal, 2021, v. 20, n. 1, p. 1, doi. 10.1186/s12936-021-03617-1
By:
- Chen, Yizhe;
- Zhu, Fangyi;
- Hammill, Jared;
- Holbrook, Gloria;
- Yang, Lei;
- Freeman, Burgess;
- White, Karen L.;
- Shackleford, David M.;
- O'Loughlin, Kathleen G.;
- Charman, Susan A.;
- Mirsalis, Jon C.;
- Guy, R. Kiplin
Publication type:
Article
Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction.
Published in:
PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0137867
By:
- Pettersson, Mariell;
- Quant, Maria;
- Min, Jaeki;
- Iconaru, Luigi;
- Kriwacki, Richard W.;
- Waddell, M. Brett;
- Guy, R. Kiplin;
- Luthman, Kristina;
- Grøtli, Morten
Publication type:
Article
8-Triazolylpurines: Towards Fluorescent Inhibitors of the MDM2/p53 Interaction.
Published in:
PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0124423
By:
- Pettersson, Mariell;
- Bliman, David;
- Jacobsson, Jimmy;
- Nilsson, Jesper R.;
- Min, Jaeki;
- Iconaru, Luigi;
- Guy, R. Kiplin;
- Kriwacki, Richard W.;
- Andréasson, Joakim;
- Grøtli, Morten
Publication type:
Article
Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds.
Published in:
PLoS ONE, 2015, v. 10, n. 4, p. 1, doi. 10.1371/journal.pone.0123598
By:
- Ortiz, Diana;
- Guiguemde, W. Armand;
- Johnson, Alex;
- Elya, Carolyn;
- Anderson, Johanna;
- Clark, Julie;
- Connelly, Michele;
- Yang, Lei;
- Min, Jaeki;
- Sato, Yuko;
- Guy, R. Kiplin;
- Landfear, Scott M.
Publication type:
Article
Anticancer Properties of Distinct Antimalarial Drug Classes.
Published in:
PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0082962
By:
- Hooft van Huijsduijnen, Rob;
- Guy, R. Kiplin;
- Chibale, Kelly;
- Haynes, Richard K.;
- Peitz, Ingmar;
- Kelter, Gerhard;
- Phillips, Margaret A.;
- Vennerstrom, Jonathan L.;
- Yuthavong, Yongyuth;
- Wells, Timothy N. C.
Publication type:
Article
On the Mechanism of Action of SJ-172550 in Inhibiting the Interaction of MDM4 and p53.
Published in:
PLoS ONE, 2012, v. 7, n. 6, p. e37518, doi. 10.1371/journal.pone.0037518
By:
- Bista, Michal;
- Smithson, David;
- Salinas, Gabriella;
- Pustelny, Katarzyna;
- Min, Jaeki;
- Pirog, Artur;
- Finch, Kristin;
- Zdzalik, Michal;
- Waddell, Brett;
- Wladyka, Benedykt;
- Kedracka-Krok, Sylwia;
- Dyer, Michael A.;
- Dubin, Grzegorz;
- Guy, R. Kiplin;
- Pecak, Aleksandra
Publication type:
Article
A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-09917-0
By:
- Drenberg, Christina D.;
- Shelat, Anang;
- Dang, Jinjun;
- Cotton, Anitria;
- Orwick, Shelley J.;
- Li, Mengyu;
- Jeon, Jae Yoon;
- Fu, Qiang;
- Buelow, Daelynn R.;
- Pioso, Marissa;
- Hu, Shuiying;
- Inaba, Hiroto;
- Ribeiro, Raul C.;
- Rubnitz, Jeffrey E.;
- Gruber, Tanja A.;
- Guy, R. Kiplin;
- Baker, Sharyn D.
Publication type:
Article
Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening.
Published in:
PLoS Neglected Tropical Diseases, 2017, v. 11, n. 12, p. 1, doi. 10.1371/journal.pntd.0006157
By:
- Ortiz, Diana;
- Guiguemde, W. Armand;
- Hammill, Jared T.;
- Carrillo, Angela K.;
- Chen, Yizhe;
- Connelly, Michele;
- Stalheim, Kayla;
- Elya, Carolyn;
- Johnson, Alex;
- Min, Jaeki;
- Shelat, Anang;
- Smithson, David C.;
- Yang, Lei;
- Zhu, Fangyi;
- Guy, R. Kiplin;
- Landfear, Scott M.
Publication type:
Article
Inactivation of the p53 pathway in retinoblastoma.
Published in:
Nature, 2006, v. 444, n. 7115, p. 61, doi. 10.1038/nature05194
By:
- Laurie, Nikia A.;
- Donovan, Stacy L.;
- Shih, Chie-Schin;
- Zhang, Jiakun;
- Mills, Nicholas;
- Fuller, Christine;
- Teunisse, Amina;
- Lam, Suzanne;
- Ramos, Yolande;
- Mohan, Adithi;
- Johnson, Dianna;
- Wilson, Matthew;
- Rodriguez-Galindo, Carlos;
- Quarto, Micaela;
- Francoz, Sarah;
- Mendrysa, Susan M.;
- Kiplin Guy, R.;
- Marine, Jean-Christophe;
- Jochemsen, Aart G.;
- Dyer, Michael A.
Publication type:
Article
Optimization of a Non-Radioactive High-Throughput Assay for Decarboxylase Enzymes.
Published in:
Assay & Drug Development Technologies, 2010, v. 8, n. 2, p. 175, doi. 10.1089/adt.2009.0249
By:
- David C. Smithson;
- Anang A. Shelat;
- Jeffrey Baldwin;
- Margaret A. Phillips;
- R. Kiplin Guy
Publication type:
Article
Evaluation of artemisinins for the treatment of acute myeloid leukemia.
Published in:
2016
By:
- Drenberg, Christina;
- Buaboonnam, Jassada;
- Orwick, Shelley;
- Hu, Shuiying;
- Li, Lie;
- Fan, Yiping;
- Shelat, Anang;
- Guy, R.;
- Rubnitz, Jeffrey;
- Baker, Sharyn;
- Drenberg, Christina D;
- Orwick, Shelley J;
- Shelat, Anang A;
- Guy, R Kiplin;
- Baker, Sharyn D
Publication type:
journal article
Screening and Development of New Inhibitors of FtsZ from M. Tuberculosis.
Published in:
PLoS ONE, 2016, v. 11, n. 10, p. 1, doi. 10.1371/journal.pone.0164100
By:
- Mathew, Bini;
- Hobrath, Judith Varady;
- Ross, Larry;
- Connelly, Michele C.;
- Lofton, Hava;
- Rajagopalan, Malini;
- Guy, R. Kiplin;
- Reynolds, Robert C.
Publication type:
Article
Short Report: Antischistosomal versus Antiandrogenic Properties of Aryl Hydantoin Ro 13-3978.
Published in:
American Journal of Tropical Medicine & Hygiene, 2014, v. 90, n. 6, p. 1156, doi. 10.4269/ajtmh.14-0029
By:
- Chunkai Wang;
- Oingjie Zhao;
- Jaeki Min;
- Muniyan, Sakthivel;
- Vargas, Mireille;
- Xiaofang Wang;
- Yuxiang Dong;
- Guy, R. Kiplin;
- Ming-Fong Lin;
- Keiser, Jennifer;
- Vennerstrom, Jonathan L.
Publication type:
Article
Diversity-oriented natural product platform identifies plant constituents targeting Plasmodium falciparum.
Published in:
Malaria Journal, 2016, v. 15, p. 1, doi. 10.1186/s12936-016-1313-7
By:
- Jin Zhang;
- Bowling, John J.;
- Smithson, David;
- Clark, Julie;
- Jacob, Melissa R.;
- Khan, Shabana I.;
- Tekwani, Babu L.;
- Connelly, Michele;
- Samoylenko, Vladimir;
- Ibrahim, Mohamed A.;
- Zaki, Mohamed A.;
- Mei Wang;
- Hester, John P.;
- Ying Tu;
- Jeffries, Cynthia;
- Twarog, Nathaniel;
- Shelat, Anang A.;
- Walker, Larry A.;
- Muhammad, Ilias;
- Guy, R. Kiplin
Publication type:
Article
Phenotypic Screens Reveal Posaconazole as a Rapidly Acting Amebicidal Combination Partner for Treatment of Primary Amoebic Meningoencephalitis.
Published in:
Journal of Infectious Diseases, 2019, v. 219, n. 7, p. 1095, doi. 10.1093/infdis/jiy622
By:
- Colon, Beatrice L;
- Rice, Christopher A;
- Guy, R Kiplin;
- Kyle, Dennis E
Publication type:
Article
Phenotypic Screens Reveal Posaconazole as a Rapidly Acting Amebicidal Combination Partner for Treatment of Primary Amoebic Meningoencephalitis.
Published in:
2019
By:
- Colon, Beatrice L;
- Rice, Christopher A;
- Guy, R Kiplin;
- Kyle, Dennis E
Publication type:
journal article
Inhibition of a viral enzyme by a small-molecule dimer disruptor.
Published in:
Nature Chemical Biology, 2009, v. 5, n. 9, p. 640, doi. 10.1038/nchembio.192
By:
- Shahian, Tina;
- Lee, Gregory M.;
- Lazic, Ana;
- Arnold, Leggy A.;
- Velusamy, Priya;
- Roels, Christina M.;
- Guy, R. Kiplin;
- Craik, Charles S.
Publication type:
Article
Reporting data from high-throughput screening of small-molecule libraries.
Published in:
2007
By:
- Inglese, James;
- Shamu, Caroline E.;
- Guy, R. Kiplin
Publication type:
Editorial
Scaffold composition and biological relevance of screening libraries.
Published in:
2007
By:
- Shelat, Anang A.;
- Guy, R. Kiplin
Publication type:
Editorial
Repositioning: the fast track to new anti-malarial medicines?
Published in:
Malaria Journal, 2014, v. 13, n. 1, p. 1, doi. 10.1186/1475-2875-13-143
By:
- Lotharius, Julie;
- Gamo-Benito, Francisco Javier;
- Angulo-Barturen, Iñigo;
- Clark, Julie;
- Connelly, Michele;
- Ferrer-Bazaga, Santiago;
- Parkinson, Tanya;
- Viswanath, Pavithra;
- Bandodkar, Balachandra;
- Rautela, Nikhil;
- Bharath, Sowmya;
- Duffy, Sandra;
- Avery, Vicky M.;
- Möhrle, Jörg J.;
- Guy, R. Kiplin;
- Wells, Timothy
Publication type:
Article

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