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- Title
New Molecules in Type 2 Diabetes: Advancements, Challenges and Future Directions.
- Authors
Chatzianagnostou, Kyriazoula; Gaggini, Melania; Suman Florentin, Adrian; Simonini, Ludovica; Vassalle, Cristina
- Abstract
Although good glycemic control in patients with type 2 diabetes (T2D) can prevent cardiovascular complications, many diabetic patients still have poor optimal control. A new class of antidiabetic drugs (e.g., glucagon-like peptide-1-GLP-1 receptor agonists, sodium-glucose co-transporters-SGLT2 inhibitors), in addition to the low hypoglycemic effect, exert multiple beneficial effects at a metabolic and cardiovascular level, through mechanisms other than antihyperglycemic agents. This review aims to discuss the effects of these new antidiabetic drugs, highlighting cardiovascular and metabolic benefits, through the description of their action mechanisms as well as available data by preclinical and clinical studies. Moreover, new innovative tools in the T2D field will be described which may help to advance towards a better targeted T2D personalized care in future.
- Subjects
TYPE 2 diabetes; GLYCEMIC control; INSULIN; PEOPLE with diabetes; CARDIOLOGICAL manifestations of general diseases; HYPERGLYCEMIA
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 11, p6218
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25116218