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- Title
Clinical outcomes and prognostic factors of patients with sepsis caused by intra-abdominal infection in the intensive care unit: a post-hoc analysis of a prospective cohort study in Korea.
- Authors
Park, Chan Hee; Lee, Jeong Woo; Lee, Hak Jae; Oh, Dong Kyu; Park, Mi Hyeon; Lim, Chae-Man; Hong, Suk-Kyung; the Korean Sepsis Alliance (KSA) investigators; Hong, Sang-Bum; Suh, Gee Young; Jeon, Kyeongman; Ko, Ryoung-Eun; Cho, Young-Jae; Lee, Yeon Joo; Lim, Sung Yoon; Park, Sunghoon; Kwak, Sang Hyun; Lee, Song-I.; Moon, Jae Young; Kim, Kyung Chan
- Abstract
Background: Sepsis is the most common cause of death in hospitals, and intra-abdominal infection (IAI) accounts for a large portion of the causes of sepsis. We investigated the clinical outcomes and factors influencing mortality of patients with sepsis due to IAI. Methods: This post-hoc analysis of a prospective cohort study included 2126 patients with sepsis who visited 16 tertiary care hospitals in Korea (September 2019–February 2020). The analysis included 219 patients aged > 19 years who were admitted to intensive care units owing to sepsis caused by IAI. Results: The incidence of septic shock was 47% and was significantly higher in the non-survivor group (58.7% vs 42.3%, p = 0.028). The overall 28-day mortality was 28.8%. In multivariable logistic regression, after adjusting for age, sex, Charlson Comorbidity Index, and lactic acid, only coagulation dysfunction (odds ratio: 2.78 [1.47–5.23], p = 0.001) was independently associated, and after adjusting for each risk factor, only simplified acute physiology score III (SAPS 3) (p < 0.001) and continuous renal replacement therapy (CRRT) (p < 0.001) were independently associated with higher 28-day mortality. Conclusions: The SAPS 3 score and acute kidney injury with CRRT were independently associated with increased 28-day mortality. Additional support may be needed in patients with coagulopathy than in those with other organ dysfunctions due to IAI because patients with coagulopathy had worse prognosis.
- Subjects
SOUTH Korea; INTRA-abdominal infections; INTENSIVE care units; PROGNOSIS; SEPSIS; COHORT analysis
- Publication
BMC Infectious Diseases, 2022, Vol 22, Issue 1, p1
- ISSN
1471-2334
- Publication type
Article
- DOI
10.1186/s12879-022-07837-x