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- Title
The efficacy of neuromuscular electrical stimulation with alternating currents in the kilohertz frequency to stimulate gait rhythm in rats following spinal cord injury.
- Authors
Tsukasa Kanchiku; Hidenori Suzuki; Yasuaki Imajo; Yuichiro Yoshida; Atsushi Moriya; Yutaka Suetomi; Norihiro Nishida; Youhei Takahashi; Toshihiko Taguchi; Kanchiku, Tsukasa; Suzuki, Hidenori; Imajo, Yasuaki; Yoshida, Yuichiro; Moriya, Atsushi; Suetomi, Yutaka; Nishida, Norihiro; Takahashi, Youhei; Taguchi, Toshihiko
- Abstract
<bold>Background: </bold>Rehabilitation facilitates the reorganization of residual/regenerated neural pathways and is key in improving motor function following spinal cord injury. Neuromuscular electrical stimulation (NMES) has been reported as being clinically effective. Although it can be used after the acute phase post-injury, the optimal stimulation conditions to improve motor function remain unclear. In this paper, we examined the effectiveness of NMES with alternating currents in the kilohertz (kHz) frequency in gait rhythm stimulation therapy.<bold>Methods: </bold>Tests were performed using 20 mature female Fischer rats. Incomplete spinal cord injuries (T9 level) were made with an IH impactor using a force of 150 kdyn, and NMES was administered for 3 days from the 7th day post-injury. The needle electrodes were inserted percutaneously near the motor point of each muscle in conscious rats, and each muscle on the left and right leg was stimulated for 15 min at two frequencies, 75 Hz and 8 kHz, to induce a gait rhythm. Motor function was evaluated using Basso, Beattie, Bresnahan (BBB) scores and three-dimensional (3D) gait analysis. Rats were divided into four groups (5 rats/group), including the NMES treatment 75-Hz group (iSCI-NMES 75 Hz), 8-kHz group (iSCI-NMES 8 kHz), injury control group (iSCI-NT), and normal group (Normal-CT), and were compared.<bold>Results: </bold>There was no significant difference in BBB scores among the three groups. In 3D gait analysis, compared with the injury control group, the 8-kHz group showed a significant improvement in synergistic movement of both hindlimbs.<bold>Conclusion: </bold>We suggest that kHz stimulation is effective in gait rhythm stimulation using NMES.
- Subjects
NEUROMUSCULAR system; ELECTRIC stimulation; ALTERNATING currents; GAIT in animals; LABORATORY rats; SPINAL cord injuries; MOTOR ability; CONTROL groups; THERAPEUTICS; ANIMALS; ANKLE; ELECTROPHYSIOLOGY; ELECTROTHERAPEUTICS; GAIT in humans; KINEMATICS; MUSCLE contraction; RATS
- Publication
BioMedical Engineering OnLine, 2015, Vol 14, p1
- ISSN
1475-925X
- Publication type
journal article
- DOI
10.1186/s12938-015-0094-5