We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A numerical study of the effect of varied blood pressure on the stability of carotid atherosclerotic plaque.
- Authors
Huahua Xiong; Xin Liu; Xiaohong Tian; Lina Pu; Heye Zhang; Minhua Lu; Wenhua Huang; Yuan-Ting Zhang
- Abstract
Background Blood pressure (BP) is associated with early atherosclerosis and plaque rupture because the BP variability can significantly affect the blood flow velocity and shear stress over the plaque. However, the mechanical response of BP variability to the plaque remains unclear. Therefore, we investigated the correlation between different maximum systolic blood pressure (SBP) and the stress distribution on plaque, as well as the stress over the plaque and blood velocity around the plaque using different BP variations, which are the BP variability in different phases during one cardiac cycle and beat-to-beat BP variability. Method We established a two-dimensional artery model with stenosis at the degree of 62.5%. Eight combinations of pulsatile pressure gradients between the inflow and outflow were implemented at the model. Three levels of fibrous cap thickness were taken into consideration to investigate the additional effect on the BP variability. Wall shear stress and stress/strain distribution over the plaque were derived as well as the oscillation shear index (OSI) to analyze the impact of the changing rate of BP. Result The stresses at diastole were 2.5% ± 1.8% lower than that at systole under the same pressure drop during one cycle. It was also found that elevated SBP might cause the immediate increment of stress in the present cycle (292% ± 72.3%), but slight reduction in the successive cycle (0.48% ± 0.4%). Conclusion The stress/strain distribution over the plaque is sensitive to the BP variability during one cardiac cycle, and the beat-to-beat BP variability could cause considerable impact on the progression of atherosclerosis in long-term.
- Subjects
BLOOD pressure measurement; ATHEROSCLEROTIC plaque; SYSTOLIC blood pressure; STRESS concentration; CARDIOVASCULAR diseases
- Publication
BioMedical Engineering OnLine, 2014, Vol 13, Issue 1, p1
- ISSN
1475-925X
- Publication type
Article
- DOI
10.1186/1475-925X-13-152