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- Title
Decreased virulence of cystic fibrosis Pseudomonas aeruginosa in Dictyostelium discoideum.
- Authors
Bradbury, Richard Stewart; Reid, David William Edward Cochrane; Inglis, Timothy John Jay; Champion, Alan Charles
- Abstract
The characteristics of clinical and environmental isolates of Pseudomonas aeruginosa from both hospital and community settings were analyzed in a eukaryotic virulence model employing the AX2 and X22 mutants of Dictyostelium discoideum. Thirty-one strains, including two Australian epidemic strains, of P. aeruginosa were analyzed, five from environmental sources, six from clinical sources other than cystic fibrosis (CF) patients and nineteen from CF patients' respiratory secretions. The majority of CF isolates almost uniquely supported the growth of D. discoideum. CF isolates of P. aeruginosa were found to be less virulent than isolates from other sources. Varying degrees of inhibition of the developmental cycle of D. discoideum when growing on CF isolates were also noted. This is the first description of P. aeruginosa isolates from clinical and environmental sources supporting the growth of D. discoideum.
- Subjects
MICROBIAL virulence; CYSTIC fibrosis; PSEUDOMONAS aeruginosa; DICTYOSTELIUM discoideum; EUKARYOTIC cells; DICTYOSTELIACEAE; EPIDEMICS
- Publication
Microbiology & Immunology, 2011, Vol 55, Issue 4, p224
- ISSN
0385-5600
- Publication type
Article
- DOI
10.1111/j.1348-0421.2011.00314.x