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- Title
The molecular basis for flexibility in the flexible filamentous plant viruses.
- Authors
DiMaio, Frank; Chen, Chun-Chieh; Yu, Xiong; Frenz, Brandon; Hsu, Yau-Heiu; Lin, Na-Sheng; Egelman, Edward H
- Abstract
Flexible filamentous plant viruses cause more than half the viral crop damage in the world but are also potentially useful for biotechnology. Structural studies began more than 75 years ago but have failed, owing to the virion's extreme flexibility. We have used cryo-EM to generate an atomic model for bamboo mosaic virus, which reveals flexible N- and C-terminal extensions that allow deformation while still maintaining structural integrity.
- Subjects
PLANT viruses; BIOTECHNOLOGY research; VIRION; BAMBOO mosaic virus; RNA viruses
- Publication
Nature Structural & Molecular Biology, 2015, Vol 22, Issue 8, p642
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb.3054