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- Title
Synthesis of 4-Hydroxyiso1eucine by the Aldolase—Transaminase Coupling Reaction and Basic Characterization of the Aldolase from Arthrobacter simplex AKU 626.
- Authors
Ogawa, Jun; Yamanaka, Hiroyuki; Mano, Junichi; Doi, Yuko; Horinouchi, Nobuyuki; Kodera, Tomohiro; Nio, Noriki; Smirnov, Sergey V.; Samsonova, Natalya N.; Kozlov, Yury I.; Shimizu, Sakayu
- Abstract
The article presents a study which synthesizes 4-hydroxyisoleucine (4-HIL) by aldolase-transaminase coupling reaction and basic characterization of the aldolase purified Arthrobacter simplex AKU 626. It describes the screening of an aldolase-producing bacterium. It is revealed that A. simplex AKU 626 synthesized 4-HIL from acetaldehyde, alpha-ketobutyrate and L-glutamate with Escherichia coli harboring the branched chain amino acid transaminase gene.
- Subjects
CHEMICAL research; ENZYMES; CHEMICAL synthesis; AMINOTRANSFERASES; HYPOGLYCEMIC agents; ARTHROBACTER; ESCHERICHIA coli
- Publication
Bioscience, Biotechnology & Biochemistry, 2007, Vol 71, Issue 7, p1607
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1271/bbb.60655