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- Title
Dextran-Based Self-Healing Hydrogels Formed by Reversible Diels-Alder Reaction under Physiological Conditions.
- Authors
Wei, Zhao; Yang, Jian Hai; Du, Xiao Jing; Xu, Feng; Zrinyi, Miklos; Osada, Yoshihito; Li, Fei; Chen, Yong Mei
- Abstract
A dextran-based self-healing hydrogel is prepared by reversible Diels-Alder reaction under physiological conditions. Cytocompatible fulvene-modified dextran as main polymer chains and dichloromaleic-acid-modified poly(ethylene glycol) as cross-linkers are used. Both macro- and microscopic observation as well as the rheological recovery test confirm the self-healing property of the dextran-l-poly(ethylene glycol) hydrogels ('l' means 'linked-by'). In addition, scanning electrochemical microscopy is used to qualitatively and quantitatively in situ track the self-healing process of the hydrogel for the first time. It is found that the longitudinal depth of scratch on hydrogel surface almost completely healed at 37 °C after 7 h. This work represents a facile approach for fabrication of polysaccharide self-healing hydrogel, which can be potentially used in several biomedical fields.
- Subjects
HYDROGELS; POLYSACCHARIDES; DEXTRAN; SELF-healing materials; POLYETHYLENE glycol; SCANNING electrochemical microscopy
- Publication
Macromolecular Rapid Communications, 2013, Vol 34, Issue 18, p1464
- ISSN
1022-1336
- Publication type
Article
- DOI
10.1002/marc.201300494