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- Title
Direct Superacid‐Promoted Difluoroethylation of Aromatics.
- Authors
Artault, Maxime; Vitse, Kassandra; Martin‐Mingot, Agnès; Thibaudeau, Sébastien
- Abstract
Under superacid conditions, aromatic amines are directly and regioselectively 1,1‐difluoroethylated. Low temperature in situ NMR studies confirmed the presence of benzylic α‐fluoronium and α‐chloronium ions as key intermediates in the reaction. This method has a wide substrate scope and can be applied to the late‐stage functionalization of natural alkaloids and active pharmaceutical ingredients.
- Subjects
LOW temperatures; AROMATIC amines
- Publication
Chemistry - A European Journal, 2022, Vol 28, Issue 6, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202103926