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- Title
High‐Z Metal–Organic Frameworks for X‐ray Radiation‐Based Cancer Theranostics.
- Authors
Neufeld, Megan J.; Lutzke, Alec; Pratx, Guillem; Sun, Conroy
- Abstract
X‐ray radiation is commonly employed in clinical practice for diagnostic and therapeutic applications. Over the past decade, developments in nanotechnology have led to the use of high‐Z elements as the basis for innovative new treatment platforms that enhance the clinical efficacy of X‐ray radiation. Nanoscale metal–frameworks (nMOFs) are coordination networks containing organic ligands that have attracted attention as therapeutic platforms in oncology and other areas of medicine. In cancer therapy, X‐ray activated, high‐Z nMOFs have demonstrated potential as radiosensitizers that increase local radiation dose deposition and generation of reactive oxygen species (ROS). This minireview summarizes current research on high‐Z nMOFs in cancer theranostics and discusses factors that may influence future clinical application.
- Subjects
METAL-organic frameworks; COMPANION diagnostics; X-rays; REACTIVE oxygen species
- Publication
Chemistry - A European Journal, 2021, Vol 27, Issue 10, p3229
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202003523