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- Title
Endometrial carcinomas with dyshesive, eosinophilic, and vacuolated (histiocyte-like) tumor cells: a reactive-like phenotype associated with aggressive behavior.
- Authors
Travaglino, Antonio; Arciuolo, Damiano; Raffone, Antonio; Santoro, Angela; Piermattei, Alessia; Navarra, Elena; Minucci, Angelo; Mascolo, Massimo; Scaglione, Giulia; D'alessandris, Nicoletta; Valente, Michele; Inzani, Frediano; Mollo, Antonio; Insabato, Luigi; Zannoni, Gian Franco
- Abstract
Herein, we present a clinicopathological and molecular analysis of four cases of endometrial carcinoma (EC) diffusely exhibiting dyshesive cells with wide eosinophilic and vacuolated cytoplasm (histiocyte-like tumor cells, HLTCs). We compared these HLTCs to similar cells found in microcystic, elongated and fragmented (MELF) pattern (n = 20) or after neoadjuvant chemotherapy (NAC) (n = 5). The four cases were endometrioid, serous, clear cell, and gastric-type; all were at FIGO stage ≥ III. HLTCs showed an epithelial Müllerian phenotype and at least focal CK20, HNF1β, and CK5/6 expression, with aberrant e-cadherin and β-catenin expression; two cases were MMR-deficient, and one was p53-abnormal; all were POLE wild type. MELF-associated and NAC-associated HLTCs showed similar morphological/immunophenotypical features. However, MELF-associated HLTCs were mainly intraglandular and inflammation-associated, did not form a distinct tumor component, and showed no relationship with lymph node metastases. In conclusion, different histotypes of EC may show a prominent HLTC component, which shows peculiar morphological/immunophenotypical features and appears associated with aggressive behavior.
- Subjects
TREATMENT of endometrial cancer; MACROPHAGES; CANCER chemotherapy; PHENOTYPES; IMMUNOPHENOTYPING
- Publication
Virchows Archiv: European Journal of Pathology, 2023, Vol 482, Issue 3, p635
- ISSN
0945-6317
- Publication type
Article
- DOI
10.1007/s00428-022-03411-7