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- Title
Influence of sarcopenia on bone health parameters in a group of eumenorrheic obese premenopausal women.
- Authors
Hammoud, Emneh; Toumi, Hechmi; Jacob, Christophe; Pinti, Antonio; Lespessailles, Eric; El Hage, Rawad
- Abstract
<bold>Introduction: </bold>The aim of this study was to compare bone mineral density (BMD) and geometric indices of hip bone strength in a group of obese sarcopenic premenopausal women (n = 27) and a group of obese premenopausal women with normal appendicular lean mass (ALM)/body mass index ratio (BMI) (n = 26).<bold>Materials and Methods: </bold>The ALM/BMI criterion of The Foundation for the National Institute of Health was used; women with an ALM/BMI ratio < 0.512 m2 were considered obese sarcopenic. Body composition and bone variables were measured by DXA. DXA measurements were completed for the whole body (WB), lumbar spine (L1-L4), total hip (TH) and femoral neck (FN). Hip geometry parameters including cross-sectional area (CSA), cross-sectional moment of inertia (CSMI), section modulus (Z), strength index (SI) and buckling ratio (BR) were derived by DXA.<bold>Results: </bold>Age, weight and BMI were not significantly different between the two groups. Height, lean mass, skeletal muscle mass index, ALM and the ratio ALM/BMI were significantly higher in obese women with normal ALM/BMI ratio compared to obese sarcopenic women. Fat mass percentage was significantly higher in obese sarcopenic women compared to obese women with normal ALM/BMI ratio. WB BMC, TH BMD, FN BMD, CSA, CSMI and Z were significantly higher in obese women with normal ALM/BMI ratio compared to obese sarcopenic women. In the whole population (n = 53), ALM and the ratio ALM/BMI were positively correlated to WB BMC, CSA, CSMI and Z.<bold>Conclusion: </bold>The present study suggests that sarcopenia negatively influences bone mineral density and hip geometry parameters before menopause in eumenorrheic obese women.
- Subjects
SARCOPENIA; BONE density; BODY mass index; LUMBAR vertebrae; SKELETAL muscle; OBESITY complications; PERIMENOPAUSE; OBESITY; BODY composition; BONES; PHOTON absorptiometry; BODY weight
- Publication
Journal of Bone & Mineral Metabolism, 2020, Vol 38, Issue 3, p385
- ISSN
0914-8779
- Publication type
journal article
- DOI
10.1007/s00774-019-01071-3