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- Title
Effect of gene polymorphism on bleeding complications in Chinese Han patients taking warfarin.
- Authors
Xia, Xiaotong; Fu, Jinglan; Wu, Tingting; Chen, Wenjun; Jiang, Shaojun; Lv, Meina; Zhang, Jinhua
- Abstract
Purpose: The purpose of this study was to analyse the effects of demographic factors, clinical factors, and genetic polymorphisms of related gene loci on warfarin bleeding-related complications in the Han population. Methods: Retrospective medical record review. The study cases were patients treated at the Fujian Medical University Union Hospital from March 2016 to February 2020, and all received regular warfarin anticoagulation treatment for at least 3 months, and were provided the initial standard dose and stable dose of warfarin. Results: Data were collected from 451 qualifying patients (47% male, 53% female). The average age of patients was 53.8 ± 12.2 years, and the average body surface area was 1.6 ± 0.18 m2. There were nine major bleeding events and 141 minor bleeding events. In the univariate logistic analysis, the p-value of the four factors body weight, body surface area (BSA), amiodarone, and rs429358 was < 0.10. However, the final p-values for amiodarone and rs429358 were < 0.05 in the multifactorial logistic analysis. Conclusions: The ApoE (rs429358) gene polymorphism influences bleeding complications in Chinese Han patients treated with warfarin. The sample size of this study was relatively small; hence an international study with a larger sample size is needed in the future.
- Subjects
CHINA; STATISTICS; STATISTICAL significance; ACQUISITION of data methodology; ACADEMIC medical centers; BODY weight; WARFARIN; TIME; MULTIVARIATE analysis; GENETIC polymorphisms; RETROSPECTIVE studies; TREATMENT duration; SOCIOECONOMIC factors; MEDICAL records; AMIODARONE; DESCRIPTIVE statistics; LOGISTIC regression analysis; DATA analysis software; HEMORRHAGE
- Publication
European Journal of Clinical Pharmacology, 2022, Vol 78, Issue 2, p205
- ISSN
0031-6970
- Publication type
Article
- DOI
10.1007/s00228-021-03204-y