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- Title
Importance of cytochrome P450 (CYP450) in adverse drug reactions due to drug-drug interactions: a PharmacoVigilance study in France.
- Authors
Danton, Anne; Montastruc, François; Sommet, Agnès; Durrieu, Geneviève; Bagheri, Haleh; Bondon-Guitton, Emmanuelle; Lapeyre-Mestre, Maryse; Montastruc, Jean-Louis
- Abstract
Objective: Our aim was to characterize Adverse Drug Reactions (ADRs) related to drug-drug interactions (DDIs) related to involvement of cytochrome P450 (CYP450) isoenzymes in a pharmacovigilance database. Methods: ADRs recorded by Midi-Pyrénées PharmacoVigilance center (France) between 1 January and 31 August 2008 were extracted from the French PharmacoVigilance Database (FPVD). Results: Among the 1,205 reported ADRs, 16 (1.3 %), can be explained by involvement of CYP450 isoenzymes (including 4 'serious'). All interactions involved CYP inhibitors, mainly for CYP3A4/5. Conclusion: The percentage of ADRs reported in the pharmacovigilance database and related to CYP450-induced DDIs appears to be relatively low (~ 1-2 %).
- Subjects
FRANCE; DATABASES; DRUG interactions; DRUG side effects; HEALTH; ISOENZYMES; PHARMACOLOGY; CYTOCHROME P-450
- Publication
European Journal of Clinical Pharmacology, 2013, Vol 69, Issue 4, p885
- ISSN
0031-6970
- Publication type
Article
- DOI
10.1007/s00228-012-1394-3