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- Title
Evaluation of the Prognostic and Predictive Value of HER-1/EGFR in Breast Cancer Patients Participating in a Randomized Study with Dose-Dense Sequential Adjuvant Chemotherapy.
- Authors
Tzaida, Olympia; Gogas, Helen; Dafni, Urania; Kyroudi, Aspasia; Papaspyrou, Irene; Kyriakou, Vasiliki; Malamou-Mitsi, Vasiliki; Alamani, Maria; Skopa, Chrisoula; Kostopoulos, Ioannis; Kastritis, Efstathios; Pectasides, Dimitrios; Briasoulis, Evangelos; Kalofonos, Haralabos P.; Aravantinos, Gerasimos; Fountzilas, George; Arapantoni-Dadioti, Petroula
- Abstract
Background: To assess the prognostic and predictive significance of HER-1/EGFR protein levels in high-risk patients with breast cancer treated with dose-dense sequential adjuvant chemotherapy. Methods: 595 high-risk breast cancer patients were treated with adjuvant anthracycline-based dose-dense sequential chemotherapy (E-CMF vs. E-T-CMF). Disease-free survival (DFS) was the primary end point. HER-1/EGFR was assessed by immunohistochemistry (IHC) in 312 patients. Results: HER-1/EGFR expression was detected in 54 of 312 patients (17%). Positive expression of HER-1/EGFR was significantly associated with negative receptor status (52 vs. 17%, p < 0.001), worse histological grade (70 vs. 45%, p = 0.001), HER-2 overexpression (46 vs. 27%, p = 0.01) and positive p53 expression (48 vs. 19%, p < 0.001). With a median follow-up of 7 years, the total number of relapses was 105 (34%), and the total number of deaths 69 (22%). The analysis for DFS provides significant evidence that the HER-1/EGFR effect on the risk of disease progression was different according to treatment (interaction p = 0.02). Regarding overall survival, a trend towards a significant difference for an interaction of HER-1/EGFR and treatment was found (p = 0.07). Conclusion: The present study demonstrated a differential effect of positive HER-1/EGFR expression in the two treatment groups, with HER-1/EGFR being a negative prognostic marker in the absence of paclitaxel. Copyright © 2008 S. Karger AG, Basel
- Subjects
PROGNOSIS; EPIDERMAL growth factor; GROWTH factors; BREAST cancer; CANCER; DRUG therapy
- Publication
Oncology, 2007, Vol 72, Issue 5/6, p388
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000113148