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- Title
Can early, tight glycaemic control prevent post-transplant diabetes mellitus?
- Authors
Laghrib, Yassine; Block, Christophe De; Abramowicz, Daniel; Hellemans, Rachel
- Abstract
In kidney failure, uraemic toxins and a sedentary lifestyle can induce insulin resistance, although patients may remain normoglycaemic because of a decreased appetite, reduced gluconeogenesis and impaired degradation of insulin [[1]]. Early post-transplant hyperglycaemia (EPTH) occurs in more than 75% of patients after kidney transplantation (KT), often evolving towards post-transplant diabetes mellitus (PTDM), defined as newly diagnosed diabetes >45 days after transplantation [[1]]. However, several protocol violations might have blurred the benefit of early basal insulin intervention: three patients did not receive insulin (although needed), insulin was not stopped in four patients despite normal glycaemia and one patient declined treatment.
- Subjects
GLYCEMIC control; KIDNEY transplantation; DIABETES; SODIUM-glucose cotransporter 2 inhibitors
- Publication
Nephrology Dialysis Transplantation, 2023, Vol 38, Issue 2, p309
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfac129