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- Title
Tempol or candesartan prevents high-fat diet-induced hypertension and renal damage in spontaneously hypertensive rats.
- Authors
Sungjin Chung; Cheol Whee Park; Seok Joon Shin; Ji Hee Lim; Hyun Wha Chung; Dong-Ye Youn; Hyung Wook Kim; Byung Soo Kim; Jeong-Hwa Lee; Gheun-Ho Kim; Yoon Sik Chang
- Abstract
Background. Obesity has been strongly associated with the development and aggravation of hypertension and chronic kidney disease. To date, the systemic renin–angiotensin system (RAS) has been known to involve in obesity-induced tissue damage and hypertension. However, the intrarenal mechanism whereby obesity induces and aggravates hypertension and renal disease remains poorly understood. Therefore, we investigated the role of intrarenal RAS and oxidative stress in diet-induced hypertension and renal inflammation in spontaneously hypertensive rats (SHR) fed a high-fat diet.
- Subjects
CANDESARTAN; HYPERTENSION; KIDNEY diseases; RATS; DIET in disease; OBESITY
- Publication
Nephrology Dialysis Transplantation, 2010, Vol 25, Issue 2, p389
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfp472