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- Title
P-173 RECURRENCE PREDICTORS IN INTENTIONAL LIMITED RESECTION FOR CT1AN0M0, GROUND GLASS OPACITY-DOMINANT LUNG ADENOCARCINOMAS.
- Authors
Matsumura, Yuki; Yoshida, J.; Ishii, G.; Aokage, K.; Hishida, T.; Nagai, K.
- Abstract
Objectives: We recently reported that, in our in-house prospective trial of intentional limited resection (ILR) for pulmonary ground glass opacity (GGO)-dominant adenocarcinomas ≤2 cm, 4 (15%) of 26 patients developed possible cut-end recurrence more than 5 years after ILR. This urged us to seek recurrence predictors based on the entire ILR population at out institution.Methods: Between 1992 and 2007, 68 patients underwent ILR (7 segmentectomies and 61 wedge resections) for peripheral, GGO-dominant, cT1aN0M0 adenocarcinomas ≤2 cm in our hospital. We retrospectively reviewed their clinicopathological characteristics and determined the predictive factors for recurrence, paying special attention to consolidation/tumour (C/T) ratio on thin-section CT, surgical margin, and new IASLC/ATS/ERS classification of adenocarcinoma.Results: Median age was 64 years (range 30-81), and 25 (37%) were men. Median follow-up period was 95 months (range 48-156 months), and 6 (9%) patients developed recurrence. All recurrent tumours had pathologically invasive components (acinar, papillary, micropapillary, and/or solid subtypes), while only 13 (21%) of the remaining 62 patients without recurrence had invasive components, with a statistically significant prevalence difference (P < 0.01). All patients with recurrence had tumours of C/T ratio >0 (mixed GGO), compared to 30 (48%) without recurrence (P = 0.02). Even among 35 patients of C/T ratio ≤0.25, 6 (17%) had invasive components. There were no significant differences in surgical margin, preoperative tumour size, or resection extent between the groups.Conclusions: Pathologically invasive components and C/T ratio >0 (mixed GGO) were significant predictors of recurrence after ILR. Such predictors, especially preoperative factors, need to be established to securely indicate ILR for small GGO-dominant adenocarcinomas.Disclosure: No significant relationships.
- Publication
Interactive Cardiovascular & Thoracic Surgery, 2014, Vol 18, Issue suppl_1, pS45
- ISSN
1569-9293
- Publication type
Article
- DOI
10.1093/icvts/ivu167.173