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- Title
Genomic Determinants of Early Recurrences in Low-Stage, Low-Grade Endometrioid Endometrial Carcinoma.
- Authors
Safdar, Nida S; Stasenko, Marina; Selenica, Pier; Martin, Axel S; Silva, Edaise M da; Sebastiao, Ana Paula Martins; Krystel-Whittemore, Melissa; Abu-Rustum, Nadeem R; Reis-Filho, Jorge S; Soslow, Robert A; Shen, Ronglai; Mueller, Jennifer J; Oliva, Esther; Weigelt, Britta
- Abstract
Low-stage, low-grade endometrioid endometrial carcinoma (EEC), the most common histologic type of endometrial cancer, typically has a favorable prognosis. A subset of these cancers, however, displays an aggressive clinical course with early recurrences, including distant relapses. All statistical tests were 2-sided. Using a combination of whole-exome and targeted capture sequencing of 65 FIGO stage IA and IB grade 1 EECs treated with surgery alone, we demonstrate that chromosome 1q gain (odds ratio [OR] = 8.09, 95% confidence interval [CI] = 1.59 to 54.6; P = .02), PIK3CA mutation (OR = 9.16, 95% CI = 1.95 to 61.8; P = .01), and DNA mismatch repair-deficient molecular subtype (OR = 7.92, 95% CI = 1.44 to 87.6; P = .02) are independent predictors of early recurrences within 3 years in this patient population. Chromosome 1q gain was validated in an independent dataset of stage I grade 1 EECs subjected to whole-exome sequencing. Our findings expand on the repertoire of genomic parameters that should be considered in the evaluation of patients with low-stage, low-grade EEC.
- Publication
JNCI: Journal of the National Cancer Institute, 2022, Vol 114, Issue 11, p1545
- ISSN
0027-8874
- Publication type
Article
- DOI
10.1093/jnci/djac119