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- Title
Upregulation of Plasma Insulin-Like Growth Factor Binding Protein 2 Levels After Biliopancreatic Diversion in Humans.
- Authors
Li, Zhuo; Martin, Julie; Poirier, Paul; Caron-Cantin, Sarah-Maude; Hould, Frédéric-Simon; Marceau, Simon; Marceau, Picard; Picard, Frédéric
- Abstract
The biliopancreatic diversion surgery with duodenal switch (BPD-DS) is a surgical procedure that not only induces significant weight loss, but also promotes remission of diabetes. However, the mechanism responsible for this insulin-potentiating effect (both on sensitivity and production) is not yet clearly understood. The insulin-like growth factor (IGF) binding protein 2 (IGFBP-2) is a 36 kDa circulating protein that has been recently suggested to modulate insulin sensitization and fat accumulation. In humans, a low-circulating concentration of IGFBP-2 has been associated with obesity and insulin resistance. We thus tested the hypothesis that BPD-DS would trigger an increase in IGFBP-2 levels. Plasma IGFBP-2 was quantified by enzyme-linked immunosorbent assay in 77 severely obese men and women before and up to 1 year after BPD-DS surgery. Baseline IGFBP-2 levels were 159 ± 17 ng/ml. Plasma IGFBP-2 levels increased significantly as soon as 24 h after BPD-DS surgery and were further augmented at both 6 months and 1 year after the surgery, reaching 748 ± 65 ng/ml. Changes in IGFBP-2 concentrations were significantly and negatively associated with blood glucose, insulin, triglycerides, and total cholesterol levels. The present findings suggest that the rise in IGFBP-2 levels is associated with the improvements in glucose and lipid metabolism in the short- and long-term after BPD-DS. The mechanisms for the augmentation in IGFBP-2 after BPD-DS and its contribution to insulin sensitization remain to be elucidated.
- Subjects
BARIATRIC surgery; INSULIN-like growth factor-binding proteins; ENZYME-linked immunosorbent assay; OVERWEIGHT persons; BLOOD sugar; INSULIN; TRIGLYCERIDES; CHOLESTEROL
- Publication
Obesity (19307381), 2012, Vol 20, Issue 7, p1469
- ISSN
1930-7381
- Publication type
Article
- DOI
10.1038/oby.2012.90