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- Title
Improved prevention and treatment strategies for differentiation syndrome contribute to reducing early mortality in patients with acute promyelocytic leukemia.
- Authors
Wu, Qian; Yang, Xiaofei; Zhang, Jingren; Xue, Mengxing; Dou, Xueqing; Ge, Zheng; Chen, Yifei; Gu, Weiying; Dong, Weimin; Cao, Hongying; Jiang, Naike; Sun, Xuemei; Liu, Zefa; Shi, Jinning; Chen, Hui; Zhang, Cixian; Min, Fengling; Sun, Hongli; Qian, Xiaoli; Yuan, Hongjian
- Abstract
This study focuses on the management of differentiation syndrome (DS) in patients with acute promyelocytic leukemia (APL). DS is a potentially life-threatening complication that can occur during treatment with all-trans retinoic acid (ATRA). The study found that a tailored treatment regimen involving prophylactic measures, such as the use of dexamethasone and the JAK1/2 inhibitor ruxolitinib, was effective in managing DS. The study also found that early suspension of ATRA due to DS increased the risk of bleeding in APL patients. The overall 30-day mortality rate was low, and the complete remission rate was high. The study concludes that personalized strategies for managing DS can reduce early death in APL patients.
- Subjects
ACUTE promyelocytic leukemia; PRELEUKEMIA; ACUTE myeloid leukemia; CYTOKINE release syndrome
- Publication
Blood Cancer Journal, 2024, Vol 14, Issue 1, p1
- ISSN
2044-5385
- Publication type
Letter
- DOI
10.1038/s41408-024-01074-y