We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Refined risk stratification helps guiding transplantation choice in adult BCR::ABL1-positive acute lymphoblastic leukemia.
- Authors
Wang, Cheng; Li, Jianfeng; Liu, Weiyang; Zhao, Lingling; Yan, Han; Yan, Yuchen; Ren, Jiayi; Peng, Lijun; Zhang, Jiaojiao; Liu, Yuanfang; Weng, Xiangqin; Zhu, Yongmei; Jing, Duohui; Mi, Jian-Qing; Wang, Jin
- Abstract
This document discusses a study that aimed to refine the risk stratification for adult patients with BCR::ABL1-positive acute lymphoblastic leukemia (BCR::ABL1 + ALL) in order to improve the management of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in therapy. The study analyzed 156 adult patients with BCR::ABL1 + ALL and found that integrating IKZF1plus genotyping and minimal residual disease (MRD) assessment could better discriminate the prognosis of these patients. The study also concluded that allo-HSCT should be spared for low-risk patients but is recommended for intermediate-risk and high-risk patients. The study identified IKZF1plus genotype and MRD positivity as independent risk factors for overall survival, event-free survival, and relapse-free survival. This article presents a study on the risk stratification of adult BCR::ABL1+ acute lymphoblastic leukemia (ALL) patients based on IKZF1plus genotyping and minimal residual disease (MRD) assessment. The study analyzed RNA-seq data from 137 patients and identified distinct developmental stages and lineage signatures associated with the IKZF1plus and non-IKZF1plus groups. The results showed that the refined risk stratification system could classify patients into low-risk, intermediate-risk, and high-risk groups, with allo-HSCT (allogeneic hematopoietic stem cell transplantation) recommended for the intermediate-risk and high-risk groups. The study provides
- Subjects
LYMPHOBLASTIC leukemia; ACUTE leukemia
- Publication
Blood Cancer Journal, 2024, Vol 14, Issue 1, p1
- ISSN
2044-5385
- Publication type
Article
- DOI
10.1038/s41408-024-01055-1